Every hypothesis is bound to explain, or, at any rate, not be inconsistent with, the whole of the facts which it professes to account for; and if there is a single one of these facts which can be shown to be inconsistent with (I do not merely mean inexplicable by, but contrary to) the hypothesis, the hypothesis falls to the ground—it is worth nothing.
Collected Essays Volume II Darwiniana
On Our Knowledge of the Causes of the Phenomena of Organic Nature
There is no need for these hypotheses to be true or even to be at all like the truth: rather one thing is sufficient for them—that they yield calculations which agree with the observations.
In Nicholas Copernicus On the Revolutions of the Heavenly Spheres
To the Reader Concerning the Hypothesis of this Work
When a hypothesis is deeply accepted it becomes a growth which only a kind of surgery can amputate.
The Log from the Sea of Cortez Chapter 17 (p. 183)
It is in the nature of a hypothesis when once a man has conceived it, that it assimilates everything to itself, as proper nourishment, and from the first moment of your begetting it, it generally grows stronger by everything you see, hear or understand.
The Life & Opinions of Tristram Shandy Book II, Chapter XVIII (p. 100)
The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this: our hypotheses ought to foretell phenomena which have not yet been observed.
The Philosophy of the Inductive Sciences Volume II Part II
Book XI, Chapter V, Section III, article 10 (p. 62)
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